7591/10 | Tocris Bioscience 7591/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7591/10

catalog :

7591/10

quantity :

10 mg (also 50 mg)

price :

196 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Gross M, Demo S, Dennison J, Chen L, Chernov Rogan T, Goyal B, et al. Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Mol Cancer Ther. 2014;13:890-901 pubmed publisher

image

image 1 :

Cat.No. 7591 - CB 839 C26H24F3N7O3S CAS No. 1439399-58-2

product information

master code :

7591

SKU :

7591/10

product name :

CB 839

unit size :

10 mg (also 50 mg)

description :

Potent glutaminase GLS1 inhibitor

target :

Glutaminase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

571.58

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CB 839 is a potent non-competitive glutaminase (GLS1) inhibitor (IC50 = 24 nM for recombinant human GAC). The compound exhibits selectivity for GLS1 over GLS2. CB 839 displays antiproliferative activity in a triple-negative breast cancer cell line (GI50 values are 19 and 55 nM against MDA-MB-231 and HCC1806, respectively); it reduces glutamine consumption and glutamate production rates in HCC1806 cells. CB 839 displays significant antitumor activity as a single agent in a patient-derived TNBC xenografts model. CB 839 inhibits the growth of basal-like HER2 cell line JIMT-1 xenografts in mice, both as a single agent and in combination with Paclitaxel (Cat. No. 1097). CB 839 works with Erlotinib (Cat. No. 7194) to reduce glucose and glutamine uptake, increase energetic stress and activate the AMP-activated protein kinase (AMPK) pathway in EGFR (del19) non-small cell lung cancer xenografts in vivo . CB 839 is orally bioavailable.

top caption :

Potent glutaminase GLS1 inhibitor

extended description :

Potent glutaminase GLS1 inhibitor

chemical name text :

N-[5-[4-[6-[[2-[3-(Trifluoromethoxy)phenyl]acetyl]amino]-3-pyridazinyl]butyl]-1,3,4-thiadiazol-2-yl]-2-pyridineacetamide

formula :

C26H24F3N7O3S

formula text :

C26H24F3N7O3S

cas num :

1439399-58-2

USD :

196 USD

product details :

Potent glutaminase GLS1 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage