7590/10 | Tocris Bioscience 7590/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7590/10

catalog :

7590/10

quantity :

10 mg (also 50 mg)

price :

135 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
DeNardo D, Brennan D, Rexhepaj E, Ruffell B, Shiao S, Madden S, et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 2011;1:54-67 pubmed publisher

image

image 1 :

Cat.No. 7590 - Pexidartinib C20H15ClF3N5 CAS No. 1029044-16-3

product information

master code :

7590

SKU :

7590/10

product name :

Pexidartinib

unit size :

10 mg (also 50 mg)

description :

Potent CSF-1R inhibitor

target :

Additional RTK Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

417.82

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Pexidartinib is a potent colony-stimulating factor-1 receptor (CSF-1R) tyrosine kinase inhibitor (IC50 = 20 nM). In the B16F10 mouse melanoma model, Pexidartinib reduces the systemic and local accumulation of macrophages without affecting Gr-1+ myeloid derived suppressor cells. When combined with tumor-specific CD8 T cell immunotherapy, Pexidartinib promotes the control of tumor growth. In the BRAFV600E-driven mouse melanoma model, Pexidartinib improves the efficacy of adoptive cell therapy with reduction of TIMs and an increase in tumor-infiltrating lymphocytes and T cells. Orally bioavailable.

top caption :

Potent CSF-1R inhibitor

extended description :

Potent CSF-1R inhibitor

chemical name text :

N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine

formula :

C20H15ClF3N5

formula text :

C20H15ClF3N5

cas num :

1029044-16-3

USD :

135 USD

product details :

Potent CSF-1R inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage