7589/10 | Tocris Bioscience 7589/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7589/10

catalog :

7589/10

quantity :

10 mg (also 50 mg)

price :

210 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7589 - Adavosertib C27H32N8O2 CAS No. 955365-80-7

product information

master code :

7589

SKU :

7589/10

product name :

Adavosertib

unit size :

10 mg (also 50 mg)

description :

Potent and selective Wee1 inhibitor

target :

Checkpoint Control Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

500.6

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Adavosertib is a potent and selective Wee1 inhibitor (IC50 = 5.2 nM). Blocks CDC2Y15 phosphorylation and Gemcitabine (Cat. No. 3259)-induced DNA damage checkpoint, leading to premature mitotic entry and apoptosis in p53-deficient tumor cell lines. Adavosertib synergizes with gemcitabine to achieve tumor regression in p53-deficient pancreatic cancer xenografts, with Olaparib (Cat. No. 7579) to inhibit SCLC xenograft tumor growth, and inhibits SCLC tumor growth in vivo . Adavosertib also potentiates the cytotoxic effects of Pemetrexed (Cat. No. 6185), Doxorubicin (Cat. No. 2252), Camptothecin (Cat. No. 1100) and Mitomycin C (Cat. No. 3258) in vitro .

top caption :

Potent and selective Wee1 inhibitor

extended description :

Potent and selective Wee1 inhibitor

chemical name text :

1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one

formula :

C27H32N8O2

formula text :

C27H32N8O2

cas num :

955365-80-7

USD :

210 USD

product details :

Potent and selective Wee1 inhibitor

alt names :

AZD 1775,MK 1775

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage