7583/5 | Tocris Bioscience 7583/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7583/5

catalog :

7583/5

quantity :

5 mg

price :

386 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7583 - SK 575 C47H53FN8O8 CAS No. 2523016-96-6

product information

master code :

7583

SKU :

7583/5

product name :

SK 575

unit size :

5 mg

description :

Potent PARP1 Degrader (PROTAC )

target :

PARP

category :

Small Molecules

purity :

98%

observed molecular weight :

876.99

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SK 575 is a potent PARP1 Degrader (PROTAC DC50 6.72 nM, 99% PARP1 degradation at 10 nM). It comprises the PARP1/2 inhibitor Olaparib (Cat. No. 7579), joined by a linker to cereblon/cullin 4A ligand Thalidomide (Cat. No. 0652). SK 575 inhibits the growth of various cancer cell lines bearing BRCA1/2 mutations with IC50 values in the nanomolar range. It effectively reduces PARP1 protein levels in mouse SW620 tumor xenograft models. SK 575 dose-dependently potentiates the antitumor activity of Temozolomide (Cat. No. 2706) and Cisplatin (Cat. No. 2251) in vivo . . PARP antibodies validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF-600-NA and MAB8095 . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Potent PARP1 Degrader (PROTAC )

extended description :

Potent PARP1 Degrader (PROTAC )

chemical name text :

N-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-12-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-12-oxododecanamide

formula :

C47H53FN8O8

formula text :

C47H53FN8O8

cas num :

2523016-96-6

USD :

386 USD

product details :

Potent PARP1 Degrader (PROTAC )

alt names :

ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase), ADPRT, ADPRT 1, ADPRTADP-ribosyltransferase NAD(+), EC 2.4.2, EC 2.4.2.30, NAD(+) ADP-ribosyltransferase 1, PARP apoptosis, PARP1, PARP-1, PARPADPRT1, poly (ADP-ribose) polymerase 1, poly (ADP-ribose) polymerase family, member 1, poly [ADP-ribose] polymerase 1, poly(ADP-ribose) polymerase, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, Poly[ADP-ribose] synthase 1, PPOL, PPOLpADPRT-1

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage