7579/10 | Tocris Bioscience 7579/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7579/10

catalog :

7579/10

quantity :

10 mg (also 50 mg)

price :

89 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Gasimli K, Raab M, Tahmasbi Rad M, Kurunci Csacsko E, Becker S, Strebhardt K, et al. Sequential Targeting of PLK1 and PARP1 Reverses the Resistance to PARP Inhibitors and Enhances Platin-Based Chemotherapy in BRCA-Deficient High-Grade Serous Ovarian Cancer with KRAS Amplification. Int J Mol Sci. 2022;23: pubmed publisher

image

image 1 :

Cat.No. 7579 - Olaparib C24H23FN4O3 CAS No. 763113-22-0

product information

master code :

7579

SKU :

7579/10

product name :

Olaparib

unit size :

10 mg (also 50 mg)

description :

Potent PARP inhibitor

target :

Poly(ADP-ribose) Polymerase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

434.47

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Olaparib is a potent PARP2 and PARP1 inhibitor (IC50 values are 1 and 5 nM, respectively). Olaparib abolishes PARP-1 activity at a concentration of 30-100 nM in SW620 cell lysates. BRCA1-deficient cell lines are hypersensitive to PARP inhibition by Olaparib in comparison with BRCA1- and BRCA2-proficient cells. Olaparib potentiates the antitumor activity of the methylating chemotherapeutic agent Temozolomide (Cat. No. 2706) in xenograft mouse model. Olaparib is orally bioavailable in rats.

top caption :

Potent PARP inhibitor

extended description :

Potent PARP inhibitor

chemical name text :

4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone

formula :

C24H23FN4O3

formula text :

C24H23FN4O3

cas num :

763113-22-0

USD :

89 USD

product details :

Potent PARP inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage