7572/10 | Tocris Bioscience 7572/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7572/10

catalog :

7572/10

quantity :

10 mg

price :

259 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

NR 162 CAS No. 2755241-73-5 Potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor

product information

master code :

7572

SKU :

7572/10

product name :

NR 162

unit size :

10 mg

description :

Potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor

target :

CaM Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

610.35

url print :

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details of functionality :

NR 162 is a potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor (IC50 = 80 nM); it exhibits no significant activity against related kinases MERTK, AXL and ABL1 and 47-fold selectivity over TYRO3 (IC50 = 3.8 M). NR 162 targets the unique pocket created by CASK GFG motif; it is a type-I inhibitor which stabilizes the active state of CASK without affecting the scaffolding function. NR 162 induces cell death in actively differentiating cells of the P19 neuronal differentiation model. NR 162 shows no toxicity in differentiated cells, or in cancer cells.

top caption :

Potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor

extended description :

Potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor

chemical name text :

4-(Cyclopentylamino)-2-((2,5-dibromo-4-methylbenzyl)amino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide

formula :

C24H30Br2N6O3

formula text :

C24H30Br2N6O3

cas num :

2755241-73-5

USD :

259 USD

product details :

Potent and selective calcium/calmodulin-dependent serine protein kinase (CASK) inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage