7569/10 | Tocris Bioscience 7569/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7569/10

catalog :

7569/10

quantity :

10 mg (also 50 mg)

price :

169 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7569 - Verdinexor C18H12F6N6O CAS No. 1392136-43-4

product information

master code :

7569

SKU :

7569/10

product name :

Verdinexor

unit size :

10 mg (also 50 mg)

description :

Selective exportin-1 (XPO1/CRM1) inhibitor

target :

Antiviral Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

442.32

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Verdinexor is a selective exportin-1 (XPO1/CRM1) inhibitor. It potently inhibits influenza virus ribonucleoprotein (vRNP) export by disrupting XPO1-NEP binding and the replication of influenza virus A and B strains in vitro , including H1N1, H5N1 and H7N9 (IC50 values in the range 40 - 420 nM range). Verdinexor limits influenza A virus spread in mouse lung in vivo . In neuroblastoma, verdinexor suppresses cell proliferation and induces cell apoptosis. It also induces P53 nuclear accumulation and induces G0/G1 phase cell cycle arrest by activating P53 function. Verdinexor inhibits tumor growth in in vivo mouse models. Orally bioavailable.

top caption :

Selective exportin-1 (XPO1/CRM1) inhibitor

extended description :

Selective exportin-1 (XPO1/CRM1) inhibitor

chemical name text :

(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide

formula :

C18H12F6N6O

formula text :

C18H12F6N6O

cas num :

1392136-43-4

USD :

169 USD

product details :

Selective exportin-1 (XPO1/CRM1) inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage