7546/10 | Tocris Bioscience 7546/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7546/10

catalog :

7546/10

quantity :

10 mg (also 50 mg)

price :

223 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7546 - C28 C18H11F3N4O

product information

master code :

7546

SKU :

7546/10

product name :

C28

unit size :

10 mg (also 50 mg)

description :

Potent LMTK3 inhibitor

target :

LMTK3

category :

Small Molecules

purity :

98%

observed molecular weight :

356.31

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1 , IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 M) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ER .

top caption :

Potent LMTK3 inhibitor

extended description :

Potent LMTK3 inhibitor

chemical name text :

6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine

formula :

C18H11F3N4O

formula text :

C18H11F3N4O

cas num :

2764850-23-7

USD :

223 USD

product details :

Potent LMTK3 inhibitor

alt names :

AATYK3, EC 2.7.11.1, KIAA1883, lemur tyrosine kinase 3KIAA1883TYKLM3LMR3, LMR3, MNBH, PPP1R101, PRO0593, REN64, serine/threonine-protein kinase LMTK3, Stank, TYKLM3

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage