7533/2 | Tocris Bioscience 7533/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7533/2

catalog :

7533/2

quantity :

2 mg

price :

250 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7533 - ZE 132 C37H41ClN4O7S CAS No. 2566710-63-0

product information

master code :

7533

SKU :

7533/2

product name :

ZE 132

unit size :

2 mg

description :

Potent and selective PD-1/PD-L1 interaction inhibitor

target :

Additional Apoptosis-related Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

721.27

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ZE 132 binds to programmed cell death-ligand 1 (PD-L1) with high affinity (KD = 19.36 nM); it potently and selectively inhibits the interaction between programmed cell death-1 (PD-1) and PD-L1 (IC50 = 23.49 nM). ZE 132 promotes CD8+ T cell activation and improves the in vitro cytotoxic killing activity of T-cells. ZE 132 treatment can increase Cxcl9 mRNA expression and lower Tgfb1 mRNA expression in CT26 mouse colorectal cancer model. ZE 132 shows antitumor effects, inhibiting growth of CT26 tumors in mice by 64%.

top caption :

Potent and selective PD-1/PD-L1 interaction inhibitor

extended description :

Potent and selective PD-1/PD-L1 interaction inhibitor

chemical name text :

2-[[[5-Chloro-2-[(5-cyano-3-pyridinyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl][3-(dimethylamino)propyl]amino]ethanesulfonic acid

formula :

C37H41ClN4O7S

formula text :

C37H41ClN4O7S

cas num :

2566710-63-0

USD :

250 USD

product details :

Potent and selective PD-1/PD-L1 interaction inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage