chemical

7530/5

7530/5

5 mg

510 USD

7530/5

dTAG-47

5 mg

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Active Degraders

Small Molecules

97%

1076.25

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dTAG-47 is a degrader targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. Application of dTAG-47 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo . dTAG is generalizable to a range of fusion proteins; useful as an alternative to genetic methods for target validation. See also dTAG-13 and dTAG-7 . . Negative control (Cat. No. 7531) also available. . FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in. . Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

(1R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

C59H73N5O14

C59H73N5O14

2265886-81-3

510 USD

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

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