chemical

7511/10

7511/10

10 mg (also 50 mg)

106 USD

7511/10

ARN 3236

10 mg (also 50 mg)

Potent inhibitor of salt-inducible kinases

SNF1LK2/SIK2

Small Molecules

98%

336.41

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ARN 3236 is a potent of salt-inducible kinase 2 (SIK2) inhibitor (IC50 values are 1 nM, 6.63 nM and 21.63 nM for SIK2, SIK3 and SIK1 respectively). ARN 3236 inhibits centrosome separation by uncoupling the centrosome from the nucleus. It also induces cell-cycle arrest and apoptosis by attenuating the AKT/survivin pathway. ARN 3236 inhibits growth and enhances Taxol (Cat. No. 1097) sensitivity in ovarian cancer cell lines in vitro and in vivo . In human myeloid cells, ARN 3236 blocks TNF and induces IL-10 upon LPS stimulation; it also reduces the production of IL-1 upon activation of TLR4 and TLR2 signaling. In depression models, ARN 3236 exhibits antidepressant-like effects via the hippocampal CRTC1-CREB-BDNF pathway. ARN 3236 penetrates the blood-brain barrier, and it is orally bioavailable.

Potent inhibitor of salt-inducible kinases

Potent inhibitor of salt-inducible kinases

3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine

C19H16N2O2S

C19H16N2O2S

1613710-01-2

106 USD

Potent inhibitor of salt-inducible kinases

DKFZp434K1115, EC 2.7.11, EC 2.7.11.1, KIAA0781SIK-2, LOH11CR1I, QIK, QIKSNF1LK2, Qin-induced kinase, salt-inducible kinase 2, Salt-inducible protein kinase 2, salt-inducible serine/threonine kinase 2, serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SNF1-like kinase 2, SIK2, SNF1-like kinase 2

Store at -20░C