7507/10 | Tocris Bioscience 7507/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7507/10

catalog :

7507/10

quantity :

10 mg (also 50 mg)

price :

99 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Guo H, Ci X, Ahmed M, Hua J, Soares F, Lin D, et al. ONECUT2 is a driver of neuroendocrine prostate cancer. Nat Commun. 2019;10:278 pubmed publisher

image

image 1 :

Cat.No. 7507 - Evofosfamide C9H16Br2N5O4P CAS No. 918633-87-1

product information

master code :

7507

SKU :

7507/10

product name :

Evofosfamide

unit size :

10 mg (also 50 mg)

description :

Hypoxia-activated DNA alkylating agent prodrug

target :

Apoptosis Inducer Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

449.04

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Evofosfamide is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM). Evofosfamide is stable under normoxic conditions but is activated by cellular reductases in hypoxic conditions (IC50 values are 5.1 M and 0.019 M, in NSCLC cells under normoxic and hypoxic conditions, respectively). Br-IPM acts as a DNA alkylating agent, inducing intrastrand and interstrand crosslinks. Evofosfamide inhibits NEPC PDX tumor growth by 84.5% in adeno-CRPC and NEPC patient-derived xenograft models. When combined with gemcitabine (Cat. No. 3259), Evofosfamide inhibits primary tumor growth by 96% and significantly extends the survival time in the MIA PaCa-2 human pancreatic cancer orthotopic xenograft model.

top caption :

Hypoxia-activated DNA alkylating agent prodrug

applications :

Adhesion Activation

extended description :

Hypoxia-activated DNA alkylating agent prodrug

chemical name text :

(1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N -bis(2-bromoethyl)phosphorodiamidate

formula :

C9H16Br2N5O4P

formula text :

C9H16Br2N5O4P

cas num :

918633-87-1

USD :

99 USD

product details :

Hypoxia-activated DNA alkylating agent prodrug

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage