chemical

7489/10

7489/10

10 mg (also 50 mg)

228 USD

7489/10

TCH-165

10 mg (also 50 mg)

Enhancer of 20S proteasome assembly and 20S-mediated protein degradation

Proteasome Modulators

Small Molecules

98%

595.74

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TCH-165 is an enhancer of 20S proteasome assembly. TCH-165 regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation. TCH-165 enhances the proteolytic activity of the 20S proteasome by increasing substrate accessibility to the 20S catalytic chamber through 20S gate opening. TCH-165 enhances 20S-mediated degradation of IDPs, -syn, and tau in vitro , and does not induce the degradation of structured proteins such as GAPDH. TCH-165 enhances c-MYC degradation by the 20S proteasome, which reduces c-MYC levels in vivo , and is effective in bortezomib (Cat. No. 7282) resistant cells. TCH-165 down-regulates c-MYC target genes and inhibits cancer cell proliferation and tumor growth in vivo .

Enhancer of 20S proteasome assembly and 20S-mediated protein degradation

Enhancer of 20S proteasome assembly and 20S-mediated protein degradation

Ethyl (4R,5R)-rel-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate

C39H37N3O3

C39H37N3O3

1446350-60-2

228 USD

Enhancer of 20S proteasome assembly and 20S-mediated protein degradation

TCH165

Store at -20░C