7488/10 | Tocris Bioscience 7488/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7488/10

catalog :

7488/10

quantity :

10 mg (also 50 mg)

price :

302 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7488 - MRTX 849 C32H35ClFN7O2 CAS No. 2326521-71-3

product information

master code :

7488

SKU :

7488/10

product name :

MRTX 849

unit size :

10 mg (also 50 mg)

description :

Mutation-selective inhibitor of KRASG12C

target :

Ras GTPase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

604.13

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MRTX 849 is a mutant-selective inhibitor of KRASG12C (IC50 = 142 nM). MRTX 849 covalently binds to KRASG12C at the cysteine 12 residue and inhibits KRAS-dependent signal transduction by locking the protein in its inactive GDP-bound state. MRTX 849 induces pronounced tumor regression in 17 of 26 (65%) KRASG12C -positive cell lines and patient-derived xenograft models from multiple tumor types. It is orally bioavailable.

top caption :

Mutation-selective inhibitor of KRASG12C

extended description :

Mutation-selective inhibitor of KRASG12C

chemical name text :

4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-(2S)-2-piperazineacetonitrile

formula :

C32H35ClFN7O2

formula text :

C32H35ClFN7O2

cas num :

2326521-71-3

USD :

302 USD

product details :

Mutation-selective inhibitor of KRASG12C

alt names :

Adagrasib

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage