7486/50 | Tocris Bioscience 7486/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7486/50

catalog :

7486/50

quantity :

50 mg

price :

127 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7486 - Roxadustat C19H16N2O5 CAS No. 808118-40-3

product information

master code :

7486

SKU :

7486/50

product name :

Roxadustat

unit size :

50 mg

description :

HIF-PH inhibitor; erythropoietic

target :

Hydrolase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

352.35

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Roxadustat is a hypoxia-inducible factor prolyl hydroxylase enzyme (HIF-PH) inhibitor (IC50 = 591.4 nM). Roxadustat reduces basal oxygen consumption and increases glycolysis in vitro . It increases hemoglobin levels and stimulates erythropoiesis in vivo . By reducing ACE2 expression, roxadustat reduces the levels of SARS-CoV-2 viral RNA and inhibits entry, replication and secretion of infectious particles in lung epithelial cells. Roxadustat also suppresses hydroxylation and secretion of high molecular weight forms of mannose-binding lectin. The compound suppresses ion currents in pituitary tumor cells (IC50 values for inhibition of peak and late components of delayed rectifier calcium currents are 5.71 and 1.32 M, respectively). Orally bioavailable.

top caption :

HIF-PH inhibitor; erythropoietic

extended description :

HIF-PH inhibitor; erythropoietic

chemical name text :

N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine

formula :

C19H16N2O5

formula text :

C19H16N2O5

cas num :

808118-40-3

USD :

127 USD

product details :

HIF-PH inhibitor; erythropoietic

alt names :

FG 4592

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage