BCI | Tocris Bioscience 7481/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BCI

catalog :

7481/50

quantity :

50 mg

price :

151 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

DUSP6 and DUSP1 inhibitor

product information

brand :

Tocris

catalog number base :

7481

SKU :

7481/50

product name :

BCI

units size :

50 mg

description :

DUSP6 and DUSP1 inhibitor

target :

Protein Tyrosine Phosphatase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

317.42

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BCI is an allosteric inhibitor of dual specificity phosphatase DUSP6 and DUSP1 (EC50 values are 8.0 M and 13.3 M respectively). Increases P2X7 receptor expression in neuroblastoma cells, reduces cell viability of EGFR or KRAS mutant lung cancer cells, and induces apoptosis in p53-null non-small cell lung cancer cells. In an animal model of myocardial infarction, BCI improves heart function, reduces fibrosis, and reduces inflammation by inhibiting macrophage formation. Activates FGF signaling in zebrafish embryo development to increase myocardial progenitor population and heart size.

top caption :

DUSP6 and DUSP1 inhibitor

extended description :

DUSP6 and DUSP1 inhibitor

chemical name text :

3-(Cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1H-inden-1-one

formula :

C22H23NO

formula text :

C22H23NO

cas num :

15982-84-0

USD :

151 USD

product details :

DUSP6 and DUSP1 inhibitor

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage