product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
7481/50
catalog :
7481/50
quantity :
50 mg
price :
151 USD
more info or order :
Tocris Bioscience product webpage
image
image 1 :
Tocris Bioscience 7481/50 image 1
DUSP6 and DUSP1 inhibitor
product information
master code :
7481
SKU :
7481/50
product name :
BCI
unit size :
50 mg
description :
DUSP6 and DUSP1 inhibitor
target :
MKP-1
category :
Small Molecules
purity :
98%
observed molecular weight :
317.42
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
BCI is an allosteric inhibitor of dual specificity phosphatase DUSP6 and DUSP1 (EC50 values are 8.0 M and 13.3 M respectively). Increases P2X7 receptor expression in neuroblastoma cells, reduces cell viability of EGFR or KRAS mutant lung cancer cells, and induces apoptosis in p53-null non-small cell lung cancer cells. In an animal model of myocardial infarction, BCI improves heart function, reduces fibrosis, and reduces inflammation by inhibiting macrophage formation. Activates FGF signaling in zebrafish embryo development to increase myocardial progenitor population and heart size.
top caption :
DUSP6 and DUSP1 inhibitor
extended description :
DUSP6 and DUSP1 inhibitor
chemical name text :
3-(Cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1H-inden-1-one
formula :
C22H23NO
formula text :
C22H23NO
cas num :
15982-84-0
USD :
151 USD
product details :
DUSP6 and DUSP1 inhibitor
alt names :
CL100, CL100MAP kinase phosphatase 1, dual specificity phosphatase 1, Dual specificity protein phosphatase hVH1, DUSP1, DUSP6, EC 3.1.3.16, EC 3.1.3.48, HVH1, Mitogen-activated protein kinase phosphatase 1, MKP1, MKP-1dual specificity protein phosphatase 1, MKP3, Protein-tyrosine phosphatase CL100, PTPN10, PTPN10serine/threonine specific protein phosphatase, PYST1, VH1
storage :
Store at +4░C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK