7463/5 | Tocris Bioscience 7463/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7463/5

catalog :

7463/5

quantity :

5 mg

price :

355 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7463 - SJF 0628 C51H57F2N9O7S2 CAS No. 2413035-41-1

product information

master code :

7463

SKU :

7463/5

product name :

SJF 0628

unit size :

5 mg

description :

Potent BRAF Degrader (PROTAC

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1010.19

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SJF 0628 is a potent, high affinity and mutant-selective Degrader (PROTAC ) of BRAF, comprising a ligand for the von Hippel Lindau E3 ligase joined by a piperazine linker to the BRAF kinase inhibitor vemurafenib. SJF 0628 induces degradation of all 3 classes of BRAF mutant in BRAF-dependent cancer cells without inducing degradation of the BRAFWT protein. The product degrades mutant BRAFV600E in BRAF-driven cancer cell lines (DC50 = 6.8 nM - 28 nM). SJ 0628 inhibits phosphorylation of MEK and ERK in SK-MEL-28 cells (DC50 = 10 nM) and inhibits cell growth in mutant-BRAF driven cancer cells (EC50 = 37 nM). . SJF 0661 negative control (Cat. No. 7464) and B-Raf antibody validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF3424 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

Potent BRAF PROTAC

extended description :

Potent BRAF Degrader (PROTAC

chemical name text :

(2S,4R)-1-((S)-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C51H57F2N9O7S2

formula text :

C51H57F2N9O7S2

cas num :

2413035-41-1

USD :

355 USD

product details :

Potent BRAF Degrader (PROTAC

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage