7458/10 | Tocris Bioscience 7458/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7458/10

catalog :

7458/10

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7458 - iBET-BD2 C23H27FN2O4 CAS No. 2474876-09-8

product information

master code :

7458

SKU :

7458/10

product name :

iBET-BD2

unit size :

10 mg (also 50 mg)

description :

Potent and selective pan-BD2 inhibitor; orally bioavailable

target :

Bromodomain Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

414.48

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

iBET-BD2 is a potent and selective pan-BD2 inhibitor (IC50 values are 49, 98, 214 and 264 nM for BRD4BD2, BRD3BD2, BRDTBD2 and BRD2BD2, respectively). iBET-BD2 is selective for BD2 over BD1 (IC50 values are 10965, 36317, 70558, and >50119 ?M for BRD2BD1, BRD3BD1, BRD4BD1, and BRDTBD1, respectively) in a time-resolved FRET (TR-FRET) assay. iBET-BD2 (1 M) inhibits IFN- -induced protein expression of MHC class I in K562 cells. iBET-BD2 reduces the production of anti-KLH IgM antibodies in mice immunized with keyhole limpet hemocyanin (KLH). iBET-BD2 exhibits immunomodulatory activity. iBET-BD2 is orally bioavailable.

top caption :

Potent and selective pan-BD2 inhibitor; orally bioavailable

extended description :

Potent and selective pan-BD2 inhibitor; orally bioavailable

chemical name text :

4-(Acetylamino)-3-fluoro-N-(trans-4-hydroxycyclohexyl)-5-[(1S)-1-phenylethoxy]benzamide

formula :

C23H27FN2O4

formula text :

C23H27FN2O4

cas num :

2474876-09-8

USD :

219 USD

product details :

Potent and selective pan-BD2 inhibitor; orally bioavailable

alt names :

GSK046

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage