7457/10 | Tocris Bioscience 7457/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7457/10

catalog :

7457/10

quantity :

10 mg

price :

302 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Scott D, Francis Newton N, Marsh M, Coyne A, Fischer G, Moschetti T, et al. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chem Biol. 2021;28:835-847.e5 pubmed publisher

image

image 1 :

Cat.No. 7457 - CAM 833 C26H26ClFN4O5

product information

master code :

7457

SKU :

7457/10

product name :

CAM 833

unit size :

10 mg

description :

Selective orthosteric inhibitor of the BRCA2-RAD51 interaction

target :

DNA, RNA and Protein Synthesis Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

528.97

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CAM 833 a selective orthosteric inhibitor of the BRCA2-RAD51 interaction (Kd of 366 nM; IC50 of 6 M). CAM 833 has no significant off-target interactions when screened at 10 M in the Cerep ExpresSPanel. It inhibits DNA recombinase RAD51-mediated homologous recombination through binding to RAD51 at the same site as the BRCA2 FxxA motif. In cells, CAM 833 suppresses the assembly of RAD51 into damage-induced filaments at the sites of DNA damage. CAM 833 potentiates radiation-induced cytotoxicity and poly-ADP ribose polymerase (PARP)1 inhibitor -induced growth suppression in BRCA2-wild-type cells. The product is metabolically stable, does not significantly inhibit CYP450 enzymes, and is suitable for in vivo investigation.

top caption :

Selective orthosteric inhibitor of the BRCA2-RAD51 interaction

extended description :

Selective orthosteric inhibitor of the BRCA2-RAD51 interaction

chemical name text :

N-(2-((2S,4R)-2-(((S)-1-(2-Chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-hydroxypyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide

formula :

C26H26ClFN4O5

formula text :

C26H26ClFN4O5

cas num :

2758364-02-0

USD :

302 USD

product details :

Selective orthosteric inhibitor of the BRCA2-RAD51 interaction

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage