7454/10 | Tocris Bioscience 7454/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7454/10

catalog :

7454/10

quantity :

10 mg (also 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7454 - Cediranib C25H27FN4O3 CAS No. 288383-20-0

product information

master code :

7454

SKU :

7454/10

product name :

Cediranib

unit size :

10 mg (also 50 mg)

description :

Potent inhibitor of VEGFR, PDGFR and FGFR

target :

VEGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

450.51

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cediranib is a highly potent and ATP-competitive inhibitor of VEGFR2 (IC50 = 1 nM). Cediranib also potently inhibits PDGFR1, VEGFR3, VEGFR1, c-Kit, PDGFR2 and FGFR1 (IC50 values are 2, 3, 5, 5, 26 and 36 nM, respectively), and inhibits CSF-1R, Src, and Abl (IC50 values are 110, 130 and 260 nM, respectively). Cediranib induces hypoxia, prevents VEGF-induced angiogenesis and suppresses homology-directed DNA repair (HDR) factors BRCA1/2 and RAD51. Cediranib decreases cell motility, proliferation and cell viability. Cediranib is active in vivo .

top caption :

Potent inhibitor of VEGFR, PDGFR and FGFR

extended description :

Potent inhibitor of VEGFR, PDGFR and FGFR

chemical name text :

4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline

formula :

C25H27FN4O3

formula text :

C25H27FN4O3

cas num :

288383-20-0

USD :

173 USD

product details :

Potent inhibitor of VEGFR, PDGFR and FGFR

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage