7427/5 | Tocris Bioscience 7427/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7427/5

catalog :

7427/5

quantity :

5 mg

price :

420 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7427 - CG 858 C42H39F2N7O8S CAS No. 2417296-82-1

product information

master code :

7427

SKU :

7427/5

product name :

CG 858

unit size :

5 mg

description :

Selective BRAF-V600E protein Degrader (uSMITE )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

839.87

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CG 858 is a selective BRAF-V600E protein Degrader (uSMITE ). CG 858 comprises the BRAF kinase inhibitor vemurafenib linked to the E3 ligase ligand Thalidomide (Cat. No. 0652). CG 858 dose-dependently degrades BRAF-V600E but not wild type BRAF, and reduces cell viability and colony formation in HT-29 and A375 cells (DC50 values are 124 nM and 500 nM, respectively). Exhibits 88% degradation at 500 nM. CG 858 also impairs melanoma cell growth. . CG 858 negative control (Cat. No. 7428) and B-Raf antibody validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF3424 .

top caption :

Selective BRAF-V600E protein Degrader (uSMITE )

extended description :

Selective BRAF-V600E protein Degrader (uSMITE )

chemical name text :

N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]pentanamide

formula :

C42H39F2N7O8S

formula text :

C42H39F2N7O8S

cas num :

2417296-82-1

USD :

420 USD

product details :

Selective BRAF-V600E protein Degrader (uSMITE )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage