7425/5 | Tocris Bioscience 7425/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7425/5

catalog :

7425/5

quantity :

5 mg

price :

413 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7425 - CG 428 C43H43FN10O6 CAS No. 2412055-93-5

product information

master code :

7425

SKU :

7425/5

product name :

CG 428

unit size :

5 mg

description :

Potent tropomyosin receptor kinase (TRK) Degrader

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

814.88

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CG 428 is a potent tropomyosin receptor kinase (TRK) Degrader (uSMITE ) (DC50 = 0.36 nM). CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). CG 428 shows selectivity for TRKA over TRKC and TRKB (Kd values = 1nM, 4.2 nM and 28 nM, respectively). Inhibits growth of KM12 colon cancer cells (IC50 =2.9 nM) and is bioavailable. . Negative control CG 428-Neg (Cat. No. 7426), and TrkB antibodies validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF1494 and AF397 .

top caption :

Potent tropomyosin receptor kinase (TRK) degrader

extended description :

Potent tropomyosin receptor kinase (TRK) Degrader

chemical name text :

2-(2,6-Dioxo-3-piperidinyl)-4-[[2-[3-[4-[6-[6-[(2R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl]-2-pyridinyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-1H-isoindole-1,3(2H)-dione

formula :

C43H43FN10O6

formula text :

C43H43FN10O6

cas num :

2412055-93-5

USD :

413 USD

product details :

Potent tropomyosin receptor kinase (TRK) Degrader

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage