7422/10 | Tocris Bioscience 7422/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7422/10

catalog :

7422/10

quantity :

10 mg (also 50 mg)

price :

170 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Potent and selective NUDT15 hydrolase inhibitor

product information

master code :

7422

SKU :

7422/10

product name :

TH 1760

unit size :

10 mg (also 50 mg)

description :

Potent and selective NUDT15 hydrolase inhibitor

target :

Hydrolase Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

426.45

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TH 1760 is a potent and selective NUDT15 (nudix hydrolase 15) inhibitor (IC50 = 29 nM). Displays selectivity for NUDT15 when assayed at 100 M against other Nudix enzymes (MTH1, NUDT2, 5, 9, 12, 14, 18, 22) and pyrophosphatases or at 10 M when assayed with a Eurofins Cerep Safety Screen44 panel. In vitro , TH 1760 treatment sensitizes cancer cell lines (NB4 and HL-60) to thiopurine.

top caption :

Potent and selective NUDT15 hydrolase inhibitor

extended description :

Potent and selective NUDT15 hydrolase inhibitor

chemical name text :

6-[[4-(1H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3H)-benzoxazolone

formula :

C20H18N4O5S

formula text :

C20H18N4O5S

cas num :

2567914-01-4

USD :

170 USD

product details :

Potent and selective NUDT15 hydrolase inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage