7420/2 | Tocris Bioscience 7420/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7420/2

catalog :

7420/2

quantity :

2 mg

price :

595 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7420 - LC 2 C59H71ClFN11O7S CAS No. 2502156-03-6

product information

master code :

7420

SKU :

7420/2

product name :

LC 2

unit size :

2 mg

description :

Selective KRAS Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

95%

observed molecular weight :

1132.8

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LC 2 is a mutant-selective KRAS Degrader (PROTAC ), comprising a ligand for the von Hippel Lindau E3 ligase joined to the KRAS inhibitor MRTX849. LC 2 induces selective degradation of KRASG12C in cancer cell lines without inducing degradation of any other mutants (DC50 = 0.25-0.76 M), leading to suppression of MAPK signaling and modulation of ERK signaling in both homozygous and heterozygous KRASG12C cancer cell lines. LC 2 inhibits phosphorylation of ERK in SW1573 cell lines. . Negative control LC 2 Epimer (Cat. No. 7421) also available. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

Selective KRAS PROTAC

extended description :

Selective KRAS Degrader (PROTAC )

chemical name text :

(2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-m

formula :

C59H71ClFN11O7S

formula text :

C59H71ClFN11O7S

cas num :

2502156-03-6

USD :

595 USD

product details :

Selective KRAS Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage