7414/50 | Tocris Bioscience 7414/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7414/50

catalog :

7414/50

quantity :

50 mg

price :

238 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Aktories P, Petry P, Glatz P, Andrieux G, Oschwald A, Botterer H, et al. An improved organotypic cell culture system to study tissue-resident macrophages ex vivo. Cell Rep Methods. 2022;2:100260 pubmed publisher

image

image 1 :

Cat.No. 7414 - DSRM-3716 C9H6IN CAS No. 58142-99-7

product information

master code :

7414

SKU :

7414/50

product name :

DSRM-3716

unit size :

50 mg

description :

Potent and reversible SARM1 NAD hydrolase inhibitor

target :

Hydrolase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

255.06

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro , DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.

top caption :

Potent and reversible SARM1 NAD hydrolase inhibitor

extended description :

Potent and reversible SARM1 NAD hydrolase inhibitor

chemical name text :

5-Iodoisoquinoline

formula :

C9H6IN

formula text :

C9H6IN

cas num :

58142-99-7

USD :

238 USD

product details :

Potent and reversible SARM1 NAD hydrolase inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage