7397/5 | Tocris Bioscience 7397/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7397/5

catalog :

7397/5

quantity :

5 mg

price :

420 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7397 - MS 39 C55H71ClFN9O7S

product information

master code :

7397

SKU :

7397/5

product name :

MS 39

unit size :

5 mg

description :

Potent and selective VHL-recruiting Degrader (PROTAC ) of mutant EGFR

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1056.74

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MS 39 is a potent, high affinity and selective Degrader (PROTAC ) of mutant epidermal growth factor receptor (EGFR), comprising gefitinib (Iressa, Cat. No. 3000) conjugated via a linker to a VHL ligand. MS 39 potently induces degradation of mutant EGFR (DC50 values are 5 nM and 3.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) lung cancer cell lines, respectively), but exhibits no significant effect in cell lines bearing wild-type EGFR at concentrations up to 10 M. MS 39 inhibits proliferation of H3255 lung cancer cells in vitro , and is bioavailable in mice following ip administration. . EGFR antibody validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF231 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

Potent and selective VHL-recruiting Degrader (PROTAC ) of mutant EGFR

extended description :

Potent and selective VHL-recruiting Degrader (PROTAC ) of mutant EGFR

chemical name text :

(2S,4R)-1-((S)-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C55H71ClFN9O7S

formula text :

C55H71ClFN9O7S

cas num :

2675490-92-1

USD :

420 USD

product details :

Potent and selective VHL-recruiting Degrader (PROTAC ) of mutant EGFR

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage