chemical

7395/5

7395/5

5 mg

420 USD

7395/5

MS 154

5 mg

Potent and selective cereblon-recruiting Degrader (PROTAC ) of mutant EGFR

Active Degraders

Small Molecules

98%

901.43

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MS 154 is a potent and selective cereblon-recruiting Degrader (PROTAC ) of mutant epidermal growth factor receptor (EGFR), comprising a cereblon-binding moiety joined by a linker to gefitinib (Iressa, Cat. No. 3000). MS 154 decreases EGFR protein levels, inhibits downstream signaling in and inhibits proliferation of mutant EGFR-bearing lung cancer cells (DC50 values are 11 and 25 nM in HCC-827 and H3255 cells, respectively; Dmax 95% at 50 nM), but not in WT-EGFR-bearing ovarian and lung cancer cells lines. Bioavailable in mice following ip administration. . Negative control (Cat. No. 7396) and EGFR antibody validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF231 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Potent and selective cereblon-recruiting Degrader (PROTAC ) of mutant EGFR

Potent and selective cereblon-recruiting Degrader (PROTAC ) of mutant EGFR

3-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)octyl)propanamide

C46H54ClFN8O8

C46H54ClFN8O8

2550393-21-8

420 USD

Potent and selective cereblon-recruiting Degrader (PROTAC ) of mutant EGFR

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