7388/100U | Tocris Bioscience 7388/100U product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7388/100U

catalog :

7388/100U

quantity :

100 ug

price :

565 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7388 - ND1-YL2 Arg-Leu-Ala-Ala-Ala-Ala-Leu-Leu-Pro-Pro-Thr-Glu-Gln-Asp-Leu-[(S)-2-(4-pentenyl)alanine]-Lys-Leu-Cha-[(S)-2-(4-pentenyl)alanine]-Tyr-NH2 (double bond covalent bridge: X-16-X-20)

product information

master code :

7388

SKU :

7388/100U

product name :

ND1-YL2

unit size :

100 ug

description :

SRC-1 peptide-based Degrader (PROTAC active in vivo

target :

Active Degraders

category :

Peptides

purity :

95%

observed molecular weight :

2385.93

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

ND1-YL2 is a peptide-based Degrader (PROTAC ) of steroid receptor co-activator 1 (SRC-1; also known as nuclear receptor coactivator 1, NCOA1). ND1-YL2 is composed of a stapled peptide that binds SRC-1 (YL2) joined by a linker to a tetrapeptide that binds UBR box domains. Upon ternary complex formation, SRC-1 is polyubiquitinated and subsequently degraded via the N-degron pathway. This Degrader induces dose-dependent degradation of SRC-1 in the MDA-MB-231 triple negative breast cancer cell line (DC50 = 10 M), and binds to the PAS-B domain of SRC-1 (Ki = 320 nM). ND1-YL2 inhibits MDA-MB-231 cell migration in vitro , and suppresses metastasis of MDA-MB-231 cells in vivo . . Src antibodies validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF3389 and NBP1-19188 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

SRC-1 peptide-based PROTAC active in vivo

extended description :

SRC-1 peptide-based Degrader (PROTAC active in vivo

formula :

C114H189N27O28

formula text :

C114H189N27O28

cas num :

2582803-80-1

USD :

565 USD

product details :

SRC-1 peptide-based Degrader (PROTAC active in vivo

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage