7379/5 | Tocris Bioscience 7379/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7379/5

catalog :

7379/5

quantity :

5 mg (also 25 mg)

price :

148 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7379 - CB 5083 C24H23N5O2 CAS No. 1542705-92-9

product information

master code :

7379

SKU :

7379/5

product name :

CB 5083

unit size :

5 mg (also 25 mg)

description :

Potent p97 ATPase inhibitor

target :

p97 ATPase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

413.48

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CB 5083 is a potent p97 inhibitor, inhibiting the D2 ATPase domain (IC50 = 11 nM). CB 5083 shows broad antitumor activity and inhibits tumor growth in vivo. CB 5083 is cytotoxic to A549 cancer cells (IC50 = 680 nM) and reduces cell viablility in a range of colorectal cancer cell lines. Increases CHOP and GRP78 protein levels, upregulates PD-L1 mRNA levels and results in the loss of aggresomes.

top caption :

Potent p97 ATPase inhibitor

extended description :

Potent p97 ATPase inhibitor

chemical name text :

1-[7,8-Dihydro-4-[(phenylmethyl)amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide

formula :

C24H23N5O2

formula text :

C24H23N5O2

cas num :

1542705-92-9

USD :

148 USD

product details :

Potent p97 ATPase inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage