RO 8191 | Tocris Bioscience 7375/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RO 8191

catalog :

7375/10

quantity :

10 mg

price :

158 USD

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

7375

SKU :

7375/10

product name :

RO 8191

Description :

IFN receptor 2 agonist

target :

IFN-alpha/beta R2

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

373.22

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RO 8191 is an IFN receptor 2 (IFNAR2) agonist (EC50 = 0.2 M). RO 8191 induces phosphorylation and activation of STAT1 and STAT2. RO 8191 inhibits hepatitis C (HCV) cell culture-produced infectious particles and HCV subgenomic replicon (IC50 values 0.20 M and 0.17 M, respectively) and inhibits hepatitis B virus replication in cell cultures (IC50 = 0.1 M). In an animal model RO 8191 inhibits prion invasion and prolongs survival; it also reverses the inhibitory effect of integrin 6 (ITGB6) on the JAK/STAT3 signaling and the epithelial-to-mesenchymal transition pathway and inhibits the proliferation, invasion, and migration of cervical cancer cells. Orally bioavailable.

extended description :

IFN receptor 2 agonist

chemical name text :

8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine

formula :

C 14 H 5 F 6 N 5 O

formula text :

C14H5F6N5O

cas num :

691868-88-9

USD :

158 USD

product details :

IFN receptor 2 agonist

alt names :

beta receptor10, human interferon alpha, human interferon alpha/beta receptor, IFNABR, IFN-alpha binding protein, IFN-alpha/beta receptor 2, IFN-alpha-REC, IFN-aR2, IFNAR2, IFNARB, IFNbR2, IFN-bR2, IFN-R, IFN-R-2, interferon (alpha, beta and omega) receptor 2, Interferon alpha binding protein, interferon alpha/beta receptor 2, interferon-alpha/beta receptor beta chain, Type I interferon receptor 2

storage :

Store at -20°C