7371/10 | Tocris Bioscience 7371/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7371/10

catalog :

7371/10

quantity :

10 mg (also 50 mg)

price :

160 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7371 - Neratinib C30H29ClN6O3 CAS No. 698387-09-6

product information

master code :

7371

SKU :

7371/10

product name :

Neratinib

unit size :

10 mg (also 50 mg)

description :

Potent HER2 receptor tyrosine kinase and EGFR kinase inhibitor

target :

EGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

557.05

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Neratinib is a potent, irreversible inhibitor of HER-2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50 = 59 nM and 92 nM, respectively). Neratinib reduces receptor autophosphorylation and proliferation of EGFR-dependent cancer cells, blocks cell-cycle progression and inhibits HER-2 signaling pathways. Neratinib suppresses proliferation of gefitinib -resistant non-small cell lung cancer cells expressing mutant EGFR. Also inhibits MST1 (IC50 = 37.7 nM). Orally bioavailable.

top caption :

Potent HER2 receptor tyrosine kinase and EGFR kinase inhibitor

extended description :

Potent HER2 receptor tyrosine kinase and EGFR kinase inhibitor

chemical name text :

(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide

formula :

C30H29ClN6O3

formula text :

C30H29ClN6O3

cas num :

698387-09-6

USD :

160 USD

product details :

Potent HER2 receptor tyrosine kinase and EGFR kinase inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage