7362/5 | Tocris Bioscience 7362/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7362/5

catalog :

7362/5

quantity :

5 mg

price :

226 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7362 - Phototrexate C20H19N7O5 CAS No. 2268033-83-4

product information

master code :

7362

SKU :

7362/5

product name :

Phototrexate

unit size :

5 mg

description :

Photoswitchable inhibitor of human dihydrofolate reductase

target :

Dihydrofolate Reductase Inhibitors

category :

Small Molecules

purity :

95%

observed molecular weight :

437.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate (Cat. No. 1230). Antifolate activity is switched on ( cis -Phototrexate) by UVA (375 nm) light; it can be switched off ( trans -Phototrexate) by blue or white light and by thermal relaxation in the dark. cis -Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared with trans -Phototrexate (IC50 = 34 M).

top caption :

Photoswitching activity of Phototrexate

extended description :

Photoswitchable inhibitor of human dihydrofolate reductase

chemical name text :

N-[4-[(1E)-2-(2,4-Diamino-6-quinazolinyl)diazenyl]benzoyl]-L-glutamic acid

formula :

C20H19N7O5

formula text :

C20H19N7O5

cas num :

2268033-83-4

USD :

226 USD

product details :

Photoswitchable inhibitor of human dihydrofolate reductase

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage