7337/10 | Tocris Bioscience 7337/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7337/10

catalog :

7337/10

quantity :

10 mg

price :

132 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7337 - Cysmethynil C25H32N2O CAS No. 851636-83-4

product information

master code :

7337

SKU :

7337/10

product name :

Cysmethynil

unit size :

10 mg

description :

ICMT inhibitor; arrests cell-cycle at G1 phase

target :

Other Transferase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

376.54

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cysmethynil is an isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor (IC50 = 2.4 M). Cysmethynil reduces growth of RAS-mutant cell lines in vitro and in vivo (EC50 = 20 M) and reduces cell viability in a variety of cell lines (IC50 = 16.8-23.3 M). Tumor growth, mTOR signaling and cell proliferation are inhibited by cysmethynil; apoptosis is induced. Cysmethynil increases p27 and p21 proteins and arrests cell-cycle at the G1 phase.

top caption :

ICMT inhibitor; arrests cell-cycle at G1 phase

extended description :

ICMT inhibitor; arrests cell-cycle at G1 phase

chemical name text :

5-(3-Methylphenyl)-1-octyl-1H-indole-3-acetamide

formula :

C25H32N2O

formula text :

C25H32N2O

cas num :

851636-83-4

USD :

132 USD

product details :

ICMT inhibitor; arrests cell-cycle at G1 phase

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage