7306/2 | Tocris Bioscience 7306/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7306/2

catalog :

7306/2

quantity :

2 mg

price :

565 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7306 - FC 11 C41H42F3N13O9S CAS No. 2271035-37-9

product information

master code :

7306

SKU :

7306/2

product name :

FC 11

unit size :

2 mg

description :

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC )

target :

FAK

category :

Small Molecules

purity :

98%

observed molecular weight :

949.92

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FC 11 is a highly potent focal adhesion kinase (FAK) PROTAC Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells. . FAK antibodies validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF4467 and MAB4467 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC )

extended description :

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC )

chemical name text :

1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1H-1,2,3-triazole-4-carboxamid

formula :

C41H42F3N13O9S

formula text :

C41H42F3N13O9S

cas num :

2271035-37-9

USD :

565 USD

product details :

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC )

alt names :

Cereblon, EC 2.7.10, FADK 1, FADK1, FADKFAK-related non-kinase polypeptide, FAK1FRNK, FAKEC 2.7.10.2, focal adhesion kinase 1, MRT2, MRT2A, pp125FAK, Protein X 0001, Protein-tyrosine kinase 2, PTK2, PTK2 protein tyrosine kinase 2

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage