7305/5 | Tocris Bioscience 7305/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7305/5

catalog :

7305/5

quantity :

5 mg (also 25 mg)

price :

170 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7305 - Defactinib C20H21F3N8O3S CAS No. 1073154-85-4

product information

master code :

7305

SKU :

7305/5

product name :

Defactinib

unit size :

5 mg (also 25 mg)

description :

Potent and selective FAK and Pyk2 inhibitor

target :

Focal Adhesion Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

510.49

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Defactinib is a potent and selective focal adhesion kinase (FAK) and proline rich tyrosine kinase 2 (Pyk2) inhibitor (IC50 = 0.6 nM at both). The compound shows 100-fold selectivity for FAK and Pyk2 over other kinases. Defactinib inhibits FAK phosphorylation in vivo (EC50 = 26 nM), and inhibits tumor growth. Defactinib also decreases the viability of thyroid cancer cells, showing greater selectivity for TT and K1 cells compared to FAK Inhibitor 14 (Cat. No. 3414) (IC50 values are 1.98 M and 10.34 M, respectively). Defactinib suppresses colony growth of Pnf cells when combined with Selumetinib (Cat. No. 6815).

top caption :

Potent and selective FAK and Pyk2 inhibitor

extended description :

Potent and selective FAK and Pyk2 inhibitor

chemical name text :

N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide

formula :

C20H21F3N8O3S

formula text :

C20H21F3N8O3S

cas num :

1073154-85-4

USD :

170 USD

product details :

Potent and selective FAK and Pyk2 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage