xStAx-VHLL | Tocris Bioscience 7298 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

xStAx-VHLL

catalog :

7298

quantity :

100 ug

price :

465 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7298 - xStAx-VHLL Ac-Arg-Arg-Trp-Pro-Arg-[(S)-2-(4-pentenyl)alanine]-Ile-Leu-Asp-[(S)-2-(4-pentenyl)alanine]-His-Val-Arg-Arg-Val-Trp-Arg-Ahx-Ala-Leu-Ala-Pro-Tyr-Ile-Pro-NH2 (double bond covalent bridge: X-6-X-10)

product information

brand :

Tocris

master code :

7298

SKU :

7298/100U

product name :

xStAx-VHLL

description :

Selective peptide-based -catenin degrader

target :

Active Degraders

category :

Peptides

unit size :

100 ug

purity :

95%

observed molecular weight :

3231.89

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Selective peptide-based -catenin Degrader. Comprises a -catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces -catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades -catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.

catalog number base :

7298

product keywords :

beta B catenin wnt signaling active degraders degrades targeted protein degradation TPD PROTAC PROTACs selective Active Degraders Beta-catenin 7298, target protein knockdown, PROTAC, SNIPER

extended description :

Selective peptide-based -catenin degrader

formula :

C 154 H 244 N 48 O 29

formula text :

C154H244N48O29

2020 USD :

465

2021 USD :

465 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage