7289/5 | Tocris Bioscience 7289/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7289/5

catalog :

7289/5

quantity :

5 mg (also 25 mg)

price :

308 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7289 - Nimbolide C27H30O7 CAS No. 25990-37-8

product information

master code :

7289

SKU :

7289/5

product name :

Nimbolide

unit size :

5 mg (also 25 mg)

description :

RNF114 inhibitor

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

466.53

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Nimbolide inhibits auto-ubiquitination of the E3 ligase RNF114 and p21 ubiquitination in vitro . This compound impairs proliferation of triple-negative breast cancer cell lines. Nimbolide also induces apoptotic cell death in a Waldenstr ms macroglobulinemia cell line (BCWM1) and inhibits tumor growth in a xenograft model of Waldenstr ms macroglobulinemia. . Nimbolide can be used for the development of Degraders that utilize RNF114 as an E3 ligase for Targeted Protein Degradation.

top caption :

RNF114 inhibitor

extended description :

RNF114 inhibitor

chemical name text :

(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-Furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-2H,5H-cyclopenta[d ]naphtho[1,8-bc:2,3-b ]difuran-6-acetic acid methyl ester

formula :

C27H30O7

formula text :

C27H30O7

cas num :

25990-37-8

USD :

308 USD

product details :

RNF114 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage