Apilimod dimesylate | Tocris Bioscience 7283 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Apilimod dimesylate

catalog :

7283

quantity :

25 mg

price :

585 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7283 - Apilimod dimesylate C23H26N6O2.2CH3SO3H CAS No. 870087-36-8

product information

brand :

Tocris

master code :

7283

SKU :

7283/25

product name :

Apilimod dimesylate

description :

Potent and selective PIKfyve inhibitor

target :

PIKFyve/PIP5K3

category :

Small Molecules

unit size :

25 mg

main entrez gene id :

200576

purity :

98%

observed molecular weight :

610.7

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective PIKfyve inhibitor (IC50 = 14 nM). Exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Inhibits cellular entry by SARS-CoV-2, MERS-CoV and MHV S pseudovirions. Reduces number of SARS-CoV-2-infected hiPSC-derived pneumocyte-like cells by 85% and inhibits SARS-CoV-2 replication in donor lung tissue. Also exhibits selective cytotoxicity in B-cell non-Hodgkin lymphoma compared with normal cells. Inhibits production of IL-12 and IL-23. Anti-inflammatory. Water-soluble.

catalog number base :

7283

product keywords :

Phosphatidylinositol 3-phosphate 5-kinase PIKfyve inhibitors inhibits potent selective SARS-COV-2 COVID-19 B cell non-hodgkin lymphoma NHL interleukins IL-23 IL-12 Other Kinases COVID-19 Endocytosis Cytokines Coronavirus 7283, phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III, Type III PIP kinase, 1-phosphatidylinositol-3-phosphate 5-kinase, CFD, Phosphatidylinositol-3-phosphate 5-kinase type III

extended description :

Potent and selective PIKfyve inhibitor

chemical name text :

4-(6-(2-(3-Methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate

formula :

C 23 H 26 N 6 O 2 .2CH 3 SO 3 H

formula text :

C23H26N6O2.2CH3SO3H

cas num :

870087-36-8

2020 USD :

585

2021 USD :

585 USD

alt names :

1-phosphatidylinositol-3-phosphate 5-kinase, EC 2.7.1.150, FAB1, FLJ37746, FYVE finger-containing phosphoinositide kinase, KIAA0981CFD, MGC40423, p235, Phosphatidylinositol-3-phosphate 5-kinase, Phosphatidylinositol-3-phosphate 5-kinase type III, phosphoinositide kinase, FYVE finger containing, PIKfyve, PIP5K, PIP5K3, PIP5K3FAB1, PIPkin-III, type III, Type III PIP kinase

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage