7283/5 | Tocris Bioscience 7283/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7283/5

catalog :

7283/5

quantity :

5 mg (also 25 mg)

price :

175 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Kettunen P, Lesnikova A, R xe4 s xe4 nen N, Ojha R, Palmunen L, Laakso M, et al. SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase. J Virol. 2023;97:e0014423 pubmed publisher

image

image 1 :

Cat.No. 7283 - Apilimod dimesylate C23H26N6O2.2CH3SO3H CAS No. 870087-36-8

product information

master code :

7283

SKU :

7283/5

product name :

Apilimod dimesylate

unit size :

5 mg (also 25 mg)

description :

Potent and selective PIKfyve inhibitor

target :

PIKFyve

category :

Small Molecules

purity :

98%

observed molecular weight :

610.7

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Apilimod dimesylate is a potent and selective PIKfyve inhibitor (IC50 = 14 nM). Exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Inhibits cellular entry by SARS-CoV-2, MERS-CoV and MHV S pseudovirions. Apilimod dimesylate reduces the number of SARS-CoV-2-infected hiPSC-derived pneumocyte-like cells by 85% and inhibits SARS-CoV-2 replication in donor lung tissue. Also exhibits selective cytotoxicity in B-cell non-Hodgkin lymphoma compared with normal cells. Inhibits production of IL-12 and IL-23. In motor neurons derived from patients with amyotrophic lateral sclerosis (ALS) Apilimod dimesylate promotes exocytosis of neurotoxic proteins and in mouse ALS models, the compound reduces pathology and prolongs survival. Anti-inflammatory. Water-soluble.

top caption :

Potent and selective PIKfyve inhibitor

extended description :

Potent and selective PIKfyve inhibitor

chemical name text :

4-(6-(2-(3-Methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate

formula :

C23H26N6O2.2CH3SO3H

formula text :

C23H26N6O2.2CH3SO3H

cas num :

870087-36-8

USD :

175 USD

product details :

Potent and selective PIKfyve inhibitor

alt names :

1-phosphatidylinositol-3-phosphate 5-kinase, EC 2.7.1.150, FAB1, FLJ37746, FYVE finger-containing phosphoinositide kinase, KIAA0981CFD, MGC40423, p235, Phosphatidylinositol-3-phosphate 5-kinase, Phosphatidylinositol-3-phosphate 5-kinase type III, phosphoinositide kinase, FYVE finger containing, PIKfyve, PIP5K, PIP5K3, PIP5K3FAB1, PIPkin-III, type III, Type III PIP kinase

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage