7278/5 | Tocris Bioscience 7278/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7278/5

catalog :

7278/5

quantity :

5 mg

price :

386 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7278 - a1A-AR Degrader 9c C38H43N11O11

product information

master code :

7278

SKU :

7278/5

product name :

a1A-AR Degrader 9c

unit size :

5 mg

description :

Selective 1A adrenergic receptor Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

829.83

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

1A-AR Degrader 9c is a selective 1A-adrenergic receptor Degrader (PROTAC DC50 = 2.86 uM, 94% 1A-adrenoceptor degradation at 10 uM for 12 h). It comprises the -adrenoceptor antagonist Prazosin (Cat. No. 0623), joined by a linker to a cereblon ligand Pomalidomide (Cat. No. 6302). 1A-AR Degrader 9c selectively downregulates 1A-adrenoceptor levels, but not 1B-AR and 1D-AR in HEK293 cells. 1A-AR Degrader 9c shows concentration-dependent antiproliferative activity in PC-3 prostate cancer cells (IC50 = 6.12 uM) in vitro , and PC-3 tumor xenografts in vivo. . 1 AR antibody validated for Western Blot also available: Catalog # MAB10298 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Selective 1A adrenergic receptor Degrader (PROTAC )

extended description :

Selective 1A adrenergic receptor Degrader (PROTAC )

chemical name text :

2-(2-(2-(2-(4-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide

formula :

C38H43N11O11

formula text :

C38H43N11O11

cas num :

2863635-02-1

USD :

386 USD

product details :

Selective 1A adrenergic receptor Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage