7270/5 | Tocris Bioscience 7270/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7270/5

catalog :

7270/5

quantity :

5 mg

price :

377 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7270 - iP300w C29H27F5N6O4 CAS No. 1889284-33-6

product information

master code :

7270

SKU :

7270/5

product name :

iP300w

unit size :

5 mg

description :

Potent p300/CBP inhibitor

target :

Histone Acetyltransferase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

618.55

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

iP300w is a potent p300/CBP inhibitor. iP300w inhibits p300-mediated H3K9 acetylation (IC50 = 33 nM). The cytotoxicity of DUX4 and overexpression of DUX4 target genes are inhibited by iP300w in vitro . In addition, the compound inhibits DUX4-mediated transcription in an animal model of facioscapulohumeral muscular dystrophy (FSHD). iP300w reduces viability and inhibits proliferation of CIC-DUX4 sarcoma (CDS) cells in vitro but not pancreatic or colorectal cancer cell lines. The compound suppresses tumor growth in a mouse CDS xenograft model. iP300w negative control iP300v (Cat. No. 7584) also available.

top caption :

Potent p300/CBP inhibitor

extended description :

Potent p300/CBP inhibitor

chemical name text :

(1 S,3 R)-3 -Fluoro-N-[(4-fluorophenyl)methyl]-2 ,3 -dihydro-5 -[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1 -[1H]indene]-1-acetamide

formula :

C29H27F5N6O4

formula text :

C29H27F5N6O4

cas num :

1889284-33-6

USD :

377 USD

product details :

Potent p300/CBP inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage