7266/5 | Tocris Bioscience 7266/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7266/5

catalog :

7266/5

quantity :

5 mg

price :

304 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7266 - SJF 8240 C58H65F2N7O11S CAS No. 2230821-68-6

product information

master code :

7266

SKU :

7266/5

product name :

SJF 8240

unit size :

5 mg

description :

c-MET PROTAC also degrades exon-14-deleted c-MET

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1106.25

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SJF 8240 is a c-MET PROTAC Degrader. Comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro . Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells. . c-MET antibodies validated for Western Blot also available: Catalog # AF276 and MAB5694 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

c-MET PROTAC also degrades exon-14-deleted c-MET

extended description :

c-MET PROTAC also degrades exon-14-deleted c-MET

chemical name text :

N-(3-Fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dic

formula :

C58H65F2N7O11S

formula text :

C58H65F2N7O11S

cas num :

2230821-68-6

USD :

304 USD

product details :

c-MET PROTAC also degrades exon-14-deleted c-MET

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage