SJF 1528 | Tocris Bioscience 7262 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SJF 1528

catalog :

7262

quantity :

5 mg

price :

345 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7262 - SJF 1528 C55H57ClFN7O8S CAS No. 2230821-38-0

product information

brand :

Tocris

master code :

7262

SKU :

7262/5

product name :

SJF 1528

description :

Potent EGFR Degrader; also degrades HER2

target :

Active Degraders

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

1030.61

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).

catalog number base :

7262

product keywords :

SJF1528 protac degraders potent EGFR epidermal growth factor receptor ERBB von Hippel Lindau VHL E3 ligases targeted protein degradation TPD HER2 Active Degraders EGFR 7262, target protein knockdown, PROTAC, SNIPER

extended description :

Potent EGFR Degrader; also degrades HER2

chemical name text :

(2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6- yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C 55 H 57 ClFN 7 O 8 S

formula text :

C55H57ClFN7O8S

cas num :

2230821-38-0

2020 USD :

345

2021 USD :

345 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage