7262/5 | Tocris Bioscience 7262/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7262/5

catalog :

7262/5

quantity :

5 mg

price :

420 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7262 - SJF 1528 C55H57ClFN7O8S CAS No. 2230821-38-0

product information

master code :

7262

SKU :

7262/5

product name :

SJF 1528

unit size :

5 mg

description :

Potent EGFR PROTAC Degrader; also degrades HER2

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1030.61

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SJF 1528 is a potent EGFR PROTAC Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. SJF 1528 comprises the EGFR inhibitor Lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells). . EGFR antibody validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF231 . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Potent EGFR PROTAC also degrades HER2

extended description :

Potent EGFR PROTAC Degrader; also degrades HER2

chemical name text :

(2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6- yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C55H57ClFN7O8S

formula text :

C55H57ClFN7O8S

cas num :

2230821-38-0

USD :

420 USD

product details :

Potent EGFR PROTAC Degrader; also degrades HER2

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage