7259/5 | Tocris Bioscience 7259/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7259/5

catalog :

7259/5

quantity :

5 mg

price :

445 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Sun Y, Revach O, Anderson S, Kessler E, Wolfe C, Jenney A, et al. Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature. 2023;: pubmed publisher

image

image 1 :

Cat.No. 7259 - TBK1 PROTAC 3i C53H74BrN9O9S CAS No. 2052306-13-3

product information

master code :

7259

SKU :

7259/5

product name :

TBK1 PROTAC 3i

unit size :

5 mg

description :

Potent TANK-binding kinase 1 (TBK1) PROTAC

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

1093.19

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TBK1 PROTAC 3i is a potent TANK-binding kinase 1 (TBK1) PROTAC Degrader (DC50 = 12 nM, Dmax = 96%). Exhibits 50-fold selectivity for TBK1 over the closely related IKK . Comprises a ligand for von-Hippel Lindau (VHL) protein joined by a linker to a TBK1-targeting moiety. Brings about near complete degradation of TBK1 in mutant K-Ras and wild-type cancer cell lines with no significant effect of proliferation. . Negative control TBK1 control PROTAC 4 (Cat. No. 7260) and TBK1 antibodies validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # AF9934 and NB100-56705 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Potent TANK-binding kinase 1 (TBK1) PROTAC

extended description :

Potent TANK-binding kinase 1 (TBK1) PROTAC

chemical name text :

(2S,4R)-1-((S)-18-(4-((5-Bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C53H74BrN9O9S

formula text :

C53H74BrN9O9S

cas num :

2052306-13-3

USD :

445 USD

product details :

Potent TANK-binding kinase 1 (TBK1) PROTAC

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage