7258/5 | Tocris Bioscience 7258/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7258/5

catalog :

7258/5

quantity :

5 mg

price :

420 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7258 - Gefitinib-based PROTAC 3 C47H57ClFN7O8S CAS No. 2230821-27-7

product information

master code :

7258

SKU :

7258/5

product name :

Gefitinib-based PROTAC 3

unit size :

5 mg

description :

Potent EGFR PROTAC Degrader

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

934.52

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Gefitinib-based PROTAC 3 is a potent EGFR PROTAC Degrader. Comprises an EGFR inhibitor gefitinib (Iressa Cat. No. 3000) conjugated to a VHL ligand via a linker. Induces EGFR degradation (DC50 values are 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively). Exhibits no degradation of wild-type EGFR at concentrations up to 10 M. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

top caption :

Potent EGFR PROTAC

extended description :

Potent EGFR PROTAC Degrader

chemical name text :

(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C47H57ClFN7O8S

formula text :

C47H57ClFN7O8S

cas num :

2230821-27-7

USD :

420 USD

product details :

Potent EGFR PROTAC Degrader

alt names :

Iressa-based PROTAC 3

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage