chemical

7254/5

7254/5

5 mg

449 USD

7254/5

ARCC 4

5 mg

Potent and selective androgen receptor Degrader (PROTAC )

Active Degraders

Small Molecules

98%

1024.18

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ARCC 4 is a potent and selective androgen receptor (AR) PROTAC Degrader (DC50 = 5 nM). Comprises an androgen receptor antagonist, enzalutamide, joined by a linker to a VHL E3 ligase ligand. Brings about degradation of ARs in VCaP and LNCaP prostate cancer cell lines (Dmax = 98% at 12h) in a proteasome-dependent manner, and inhibits cell proliferation. Also degrades clinically relevant AR mutants expressed in HEK293T cells. Exhibits no significant effect on glucocorticoid, estrogen or progesterone receptors at concentrations inducing AR degradation. . ARCC 4 negative control (Cat. No. 7255) and R/NR3C4 antibody validated for Simple Western (automated Western) instruments and Western Blot also available: Catalog # MAB58762 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license .

Potent and selective androgen receptor PROTAC

Potent and selective androgen receptor Degrader (PROTAC )

(2S,4R)-1-((S)-2-(2-(4-((4 -(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1 -biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxami

C53H56F3N7O7S2

C53H56F3N7O7S2

1973403-00-7

449 USD

Potent and selective androgen receptor Degrader (PROTAC )

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