7240/1 | Tocris Bioscience 7240/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7240/1

catalog :

7240/1

quantity :

1 mg

price :

445 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7240 - ZNL 02-096 C42H45N11O6 CAS No. 2414418-49-6

product information

master code :

7240

SKU :

7240/1

product name :

ZNL 02-096

unit size :

1 mg

description :

Potent and selective Wee1 Degrader (PROTAC )

target :

Active Degraders

category :

Small Molecules

purity :

98%

observed molecular weight :

799.89

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC ) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cells in vitro , ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines. . Wee1 antibody validated for Western Blot also available: Catalog # NBP1-33506 . . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

top caption :

Potent and selective Wee1 Degrader (PROTAC )

extended description :

Potent and selective Wee1 Degrader (PROTAC )

chemical name text :

4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

formula :

C42H45N11O6

formula text :

C42H45N11O6

cas num :

2414418-49-6

USD :

445 USD

product details :

Potent and selective Wee1 Degrader (PROTAC )

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage