7223/50 | Tocris Bioscience 7223/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7223/50

catalog :

7223/50

quantity :

50 mg

price :

188 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7223 - Dabrafenib mesylate C23H20F3N5O2S2.CH3SO3H CAS No. 1195768-06-9

product information

master code :

7223

SKU :

7223/50

product name :

Dabrafenib mesylate

unit size :

50 mg

description :

Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome

target :

Raf Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

615.66

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dabrafenib mesylate is a potent and selective Raf kinase inhibitor (IC50 values are 0.8, 3.2 and 5.0 nM for B-RafV600E, wild-type B-Raf and c-Raf, respectively). Exhibits selectivity for B-Raf over a panel of 270 other kinases. Arrests cell cycle in the G1 phase and inhibits growth of B-RafV600E mutant melanoma and colon cancer cells in vitro and in vivo . Orally bioavailable. Also inhibits NEK9 (IC50 10 nM) and CDK16. Identified as targeting human host proteins that interact with SARS-CoV-2.

top caption :

Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome

extended description :

Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome

chemical name text :

N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide methanesulfonate

formula :

C23H20F3N5O2S2.CH3SO3H

formula text :

C23H20F3N5O2S2.CH3SO3H

cas num :

1195768-06-9

USD :

188 USD

product details :

Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage