7222/50 | Tocris Bioscience 7222/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

7222/50

catalog :

7222/50

quantity :

50 mg

price :

272 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 7222 - Baricitinib C16H17N7O2S CAS No. 1187594-09-7

product information

master code :

7222

SKU :

7222/50

product name :

Baricitinib

unit size :

50 mg

description :

Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2

target :

JAK Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

371.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Baricitinib is a highly potent JAK1 and JAK2 inhibitor (IC50 values are 5.9 and 5.7 nM, respectively). Also inhibits Tyk2 (IC50 = 53 nM). Displays 100-fold selectivity for JAK1/2 over JAK3 (IC50 = 53 nM for JAK3). Binds AAK1, BIKE, GAK and MPSK1 in vitro (Kd values are 17.2, 39.8, 134.4 and 68.5 nM, respectively). Inhibits IL-6-induced STAT phosphorylation and subsequent pro-inflammatory chemokine (MPC-1) and cytokine (IL-17 and IL-22) production in PBMCs and T-cells. Displays anti-inflammatory and disease modifying effects in the rat adjuvant arthritis model. In silico modelling predicts inhibition of SARS-CoV-2 cell entry.

top caption :

Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2

extended description :

Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2

chemical name text :

1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile

formula :

C16H17N7O2S

formula text :

C16H17N7O2S

cas num :

1187594-09-7

USD :

272 USD

product details :

Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2

alt names :

INCB 28050

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage